Analysis of latest trials, comparing treatment schemes including chemotherapy with anti-EGFR monoclonal antibodies or bevacizumab is presented in this article.The data in these Crank And Shroud trials is inconsistent, but detailed analysis of FIRE-3 trial allows to distinguish a wild-type RAS patient Titanium group that benefits most from chemotherapy with cetuximab or panitumumab as 1st line metastatic colorectal cancer treatment.A final analysis of this patient group in CALGB/SWOG 80 405 trial is pending.The RAS analysis is pivotal for choice of 1st line chemotherapy.